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. 2017 Jun 22;6(8):1219–1228. doi: 10.1242/bio.025833

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© 2017. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — Laminin-332 promotes melanocyte motility. (A) Spider plots for random migration tracks of melanocytes plated without exogenous extracellular matrix (No ECM), on collagen I (Col I) or laminin-332 substrate (Lam 332), and analyzed for 16 h. (B) The particle analysis function of ImageJ was used to examine the speed of individual melanocytes on the indicated extracellular matrix substrates, with the mean speed indicated by red lines. (C) Percentage of cells that exhibited speed values within the indicated ranges when seeded on no exogenous matrix (black bars), on collagen I (white bars) or on laminin-332 (gray bars). (D) The ‘Chemotaxis and Migration Tool’ plugin for ImageJ (Ibidi) was used to examine the accumulated distance of individual melanocytes on the indicated extracellular matrix substrates, with the mean distance indicated by red lines. (E) Percentage of cells that exhibited accumulated distance values within the indicated ranges when seeded on no exogenous ECM (black bars), on collagen I (white bars) or on laminin-332 (gray bars). The data shown in the histograms (C,E) represent the mean+s.d. (n=300 cells analyzed from three independent isolates, 100 cells scored per isolate, one-way ANOVA). *P<0.05 for B-E.