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. 2017 Jun 27;6(8):1174–1179. doi: 10.1242/bio.026260

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© 2017. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 2. — Rapid wound healing and proliferative skin phenotype in Rhbdf2^P159L/P159L mice. (A) Representative images of regenerating ear tissue in eight-week-old female Rhbdf2^+/+ and Rhbdf2^{P159L/ P159L} mice at 14 days postwounding. Magnification, 4×; scale bars: 1 mm. (B) Quantification of ear hole closures shown in A. Rhbdf2^+/+ (n=6) and Rhbdf2^P159L/P159L (n=4). (C) ELISA quantitation of AREG levels in the supernatants of cultured Rhbdf2^+/+ and Rhbdf2^P159L/P159L MEKs in response to stimulation with 100 nM PMA for the indicated times. (D) H&E-stained skin sections of female Rhbdf2^+/+, Rhbdf2^cub/cub and Rhbdf2^P159L/P159L mice. Both the Rhbdf2^cub/cub and Rhbdf2^P159L/P159L mice present with significant hyperplasia (H), hyperkeratosis (arrow), enlarged sebaceous glands (S), and follicular dystrophy (F) compared with the Rhbdf2^+/+ mice. Scale bars: 100 μm (low magnification); 50 μm (high magnification).