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. 2017 Jul 6;6(8):1200–1208. doi: 10.1242/bio.026823

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© 2017. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — Th-Cre; PDi mice show a blunted response to hypoxic conditions after DREADD-mediated acute perturbation. (A) Hypoxic protocol. (B-F) CNO-DREADD-mediated inhibition of Th-Cre; PDi-defined neurons results in decreased hypoxic ventilation. Upon CNO administration, no change is seen under room air conditions in Th-Cre; PDi mice (n=11). Under hypoxic conditions, Th-Cre; PDi mice show dramatically reduced f_R (P<0.001), (P=0.0013) and (P<0.001) as compared to sibling controls (n=10). Sibling controls show no significant difference before or after CNO administration under room air conditions. Individual data points and mean±s.e.m. are shown on each graph. Statistical significance was determined using a linear mixed-effects regression model with animal type as a fixed effect. *P<0.05; **P<0.01; ***P<0.001; ns, not significant.

Inline graphic — Th-Cre; PDi mice show a blunted response to hypoxic conditions after DREADD-mediated acute perturbation. (A) Hypoxic protocol. (B-F) CNO-DREADD-mediated inhibition of Th-Cre; PDi-defined neurons results in decreased hypoxic ventilation. Upon CNO administration, no change is seen under room air conditions in Th-Cre; PDi mice (n=11). Under hypoxic conditions, Th-Cre; PDi mice show dramatically reduced f_R (P<0.001), (P=0.0013) and (P<0.001) as compared to sibling controls (n=10). Sibling controls show no significant difference before or after CNO administration under room air conditions. Individual data points and mean±s.e.m. are shown on each graph. Statistical significance was determined using a linear mixed-effects regression model with animal type as a fixed effect. *P<0.05; **P<0.01; ***P<0.001; ns, not significant.