Table 6.
Univariate association between peripheral blood biomarkers of aging and reduced RDI
| RDI ≥ 85% | RDI < 85% | OR (95% CI) | P value | |
|---|---|---|---|---|
| (N = 123) | (N = 36) | |||
| As continuous variables | ||||
| IL-6 (pg/ml) | 2.7 (3.15) | 5.7 (7.95) | 1.14 (1.04–1.25) | 0.006 |
| D-dimer (μg/ml) | 0.7 (0.58) | 1.1 (0.57) | 2.32 (1.27–4.24) | 0.006 |
| CRP (μg/ml) | 5.3 (7.42) | 6.4 (9.07) | 1.02 (0.97–1.06) | 0.47 |
| As categorical variables | ||||
| IL-6 | ||||
| Q 1, 2, 3 | 98 (79.7%) | 22 (61.1%) | ||
| Q4 | 25 (20.3%) | 14 (38.9%) | 2.49 (1.12–5.56) | 0.02 |
| D-Dimer | ||||
| Q 123 | 97 (78.9%) | 18 (51.4%) | ||
| Q4 | 26 (21.1%) | 17 (48.6%) | 3.52 (1.60–7.78) | 0.002 |
| CRP | ||||
| Q 123 | 94 (76.4%) | 26 (72.2%) | ||
| Q 4 | 29 (23.6%) | 10 (27.8%) | 1.25 (0.53–2.89) | 0.61 |
| IL-6 or D-dimer combinationa | ||||
| 0 | 79 (86.8%) | 12 (13.2%) | ||
| 1 or 2 | 44(64.7%) | 24 (35.3%) | 3.59 (1.64–8.87) | 0.001 |
Continuous variables are presented as mean (SD) and categorical variables as N (%)
RDI relative dose intensity, CRP C-reactive protein
aIL-6 or D-dimer combination: 0 = both markers in lower three quartiles; 1 = 1 of the markers in the 4th quartile; 2 = 2 of the markers in the 4th quartile