Table 2.
Cardiomyopathy scores in Wistar rats treated with doxorubicin for 4 weeks
| Dose of doxorubicin (mg/kg/w) | No. of animals | Cardiomyopathy score | |||||
|---|---|---|---|---|---|---|---|
| 0 | 1 | 1.5 | 2 | 2.5 | 3 | ||
| 4* | 8 | 0 | 2 | 3 | 3 | 0 | 0 |
| 3.5† | 7 | 2 | 2 | 2 | 1 | 0 | 0 |
| 3 | 8 | 4 | 2 | 2 | 0 | 0 | 0 |
| 2.5 | 8 | 6 | 2 | 0 | 0 | 0 | 0 |
| Saline control | 5 | 5 | 0 | 0 | 0 | 0 | 0 |
Cardiomyopathy scores are based on the percentage of myocytes showing cytoplasmic vacuolization and/or myofibrillar loss and are graded from 0 to 3 as follows: 0 = no alterations, 1 ≤ 5%, 1.5 = 5% to 15%, 2.0 = 16% to 25%, 2.5 = 26% to 35%, and 3 ≥ 35%.
*
Cardiomyopathy scores were significantly (p < 0.05) higher than in those receiving 3 mg/kg/w or less doxorubicin.
†
Cardiomyopathy scores were significantly (p < 0.05) higher than in those receiving 2.5 mg/kg/w or less doxorubicin.