Figure 2. Virus-specific T cell responses are detected in all MERS survivors.
PBMCs from healthy donors and MERS patients were stimulated with MERS-CoV structural protein-specific peptide pools for 12 hours in the presence of brefeldin A. Frequencies of MERS-CoV-specific CD4 (A, B) and CD8 (C, D) T cells (determined by IFN-γ intracellular staining) are shown. (E) Summary of total T cell responses against all four peptide pools is shown. (F) Relationship between T cell and neutralizing antibody responses is shown.