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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: J Immunol Methods. 2017 May 24;448:51–58. doi: 10.1016/j.jim.2017.05.008

Fig. 4.

Fig. 4

Pathology analysis: A and D) Liver from an NSG mouse injected with bivalent human IL-2 fusion toxin at 100 μg/kg shows unremarkable hepatic parenchyma with no increase in hepatocyte necrosis or inflammation. B and E) Liver from a mouse injected with HUT102/6TG tumor cells shows replacement of liver parenchyma by sheets of malignant cells with condensed chromatin, prominent nucleoli, an elevated nuclear: cytoplasmic ratio, and geographic necrosis. C and F) Liver from a mouse injected with both HUT102/6TG tumor cells and bivalent human IL-2 fusion toxin at 100 μg/kg shows normal hepatic parenchyma in most of the examined section and a few sporadic malignant cells.