Table 1. Inherited Variation and Primary Genetic Events in Multiple Myeloma.
| Inherited Variation | ||||
|---|---|---|---|---|
| Single-nucleotide polymorphisms (SNPs) | ||||
| Chromosome | Gene(s) | Primary tool(s) | Reference(s) | |
| 2p23.3 | DTNB and DNMT3A | GWAS | (34, 35) | |
| 3p22.1 | ULK4 and TRAK1 | |||
| 7p15.3 | DNAH11 and CDCA7L | |||
| Primary Genetic Events | ||||
| IGH@ translocations | ||||
| Translocation | Gene(s) | Primary tool(s) | Reference(s) | |
| t(4;14) at 4p16.3 | FGFR3 and MMSET | Karyotype analysis (cytogenetics), FISH, GEP, GWAS, RT-PCR or sequencing | (25) | |
| t(6;14) at 6p21 | CCND3 | (21, 23) | ||
| t(11;14)(p21;q11) | CCND1 | (21, 23, 27) | ||
| t(14;16)(q32;q23) | MAF | (24) | ||
| t(14;20)(q32;q12) | MAFB | (17, 26) | ||
| Hyperdiploidy (chromosomal trisomy) | ||||
| Chromosome(s) | Gene(s) | Primary tool(s) | Reference(s) | |
| 3, 5, 7, 9, 11, 15, 19, and 21 | GEP and FISH | (41) | ||