TABLE 4.
Multivariate regression analyses of overall mortality using Cox proportional hazards models
| Variables | Model 1 | Model 2 | ||
| HR (95% CI) | p-value | HR (95% CI) | p-value | |
| KL-6 model | ||||
| Baseline | ||||
| FVC % predicted | 0.97 (0.94–1.00) | 0.047 | ||
| DLCO % predicted | 0.91 (0.85–0.97) | <0.01 | ||
| CPI | 1.13 (1.06–1.22) | <0.01 | ||
| Serum KL-6 100 U·mL−1 | 0.98 (0.89–1.05) | 0.66 | 0.99 (0.90–1.05) | 0.78 |
| 6 month change | ||||
| Serum KL-6, 100 U·mL−1 | 1.10 (1.01–1.18) | 0.03 | 1.10 (1.02–1.18) | 0.02 |
| SP-D model | ||||
| Baseline | ||||
| FVC % predicted | 0.97 (0.93–1.00) | 0.04 | ||
| DLCO % predicted | 0.94 (0.88–1.00) | 0.054 | ||
| CPI | 1.12 (1.05–1.21) | <0.01 | ||
| Serum SP-D 10 ng·mL−1 | 1.01 (0.99–1.03) | 0.21 | 1.01 (0.99–1.03) | 0.15 |
| 6 month change | ||||
| Serum SP-D 10 ng·mL−1 | 1.03 (0.99–1.06) | 0.16 | 1.03 (0.99–1.06) | 0.12 |
HR: hazard ratio; KL-6: Krebs von den Lungen-6; FVC: forced vital capacity; DLCO: diffusing capacity of the lung for carbon monoxide; CPI: composite physiologic index; SP-D: surfactant protein-D.