Table 3.
Cortex and hippocampus fatty acid composition (%) in mice fed oleic acid-enriched or arachidonic acid-enriched diet
| Cortex | Hippocampus | |||
|---|---|---|---|---|
| OLE | ARA | OLE | ARA | |
| Palmitic acid (16:0) | 26.92 ± 0.07 | 27.04 ± 0.11 | 25.23 ± 0.14 | 24.76 ± 0.23 |
| Stearic acid (18:0) | 24.93 ± 0.19 | 25.17 ± 0.09 | 26.03 ± 0.18 | 25.72 ± 0.37 |
| Palmitoleic acid (16:1) | 0.40 ± 0.00 | 0.39 ± 0.01 | 0.43 ± 0.01 | 0.41 ± 0.00 |
| Oleic acid (18:1) | 12.13 ± 0.06 | 11.52 ± 0.06a | 12.68 ± 0.16 | 11.61 ± 0.13a |
| Linoleic acid (18:2 ω-6) | 0.61 ± 0.01 | 0.38 ± 0.02b | 0.61 ± 0.02 | 0.34 ± 0.02a |
| Arachidonic acid (20:4 ω-6) | 11.50 ± 0.03 | 12.69 ± 0.05b | 13.08 ± 0.15 | 14.65 ± 0.23a |
| Docosatetraenoic acid (22:4 ω-6) | 3.71 ± 0.02 | 4.75 ± 0.04b | 4.76 ± 0.15 | 5.82 ± 0.09b |
| Linolenic acid (18:3 ω-3) | LOQ | LOQ | 0.05 ± 0.05 | 0.02 ± 0.02 |
| Eicosapentaenoic acid (20:5 ω-3) | LOQ | LOQ | LOQ | LOQ |
| Docosahexaenoic acid (22:6 ω-3) | 19.81 ± 0.06 | 18.04 ± 0.10b | 17.14 ± 0.26 | 16.68 ± 0.38 |
| Sum of ω-6 PUFA | 15.82 | 17.82 | 18.44 | 20.81 |
| Sum of ω-3 PUFA | 19.81 | 18.07 | 17.19 | 16.69 |
Abbreviations: ARA Arachidonic acid-enriched diet, OLE Oleic acid-enriched diet, LOQ Limit of quantitation PUFA Polyunsaturated fatty acid
a p < 0.05, ARA compared with OLE. n = 8 in OLE diet group, n = 12 in ARA diet group
b p < 0.001, ARA compared with OLE. n = 8 in OLE diet group, n = 12 in ARA diet group