Table 3.
Toxicity of compounds used in the trial
| Compound | LD50 (mg/kg body weight)a | ||||
|---|---|---|---|---|---|
| G. mellonella | Rat | Mouse | |||
| Intraperitoneal | Oral | Intraperitoneal | Oral | Intraperitoneal | |
| Amsacrine | 40 | 100 | 243 | ||
| Chloroquine | 125b | 623 | 500 | ||
| Ciprofloxacin | >2000 | >2000 | >2000 | ||
| DMSO | 100 | 14,500 | 7920 | ||
| Doxorubicin | 5.5 | 16 | 698 | 1.2 | |
| Etoposide | 100 | 1784 | 58 | 215 | |
| Glucose | >2000 | 25,800 | |||
| Novobiocin | 100 | 3500 | 962 | ||
| Sodium chloride | >2000 | 3000 | 4000 | ||
| Streptomycin | 300 | 430 | 430 | ||
| Tetracycline | >2000 | 6443 | 318 | 2759 | 368 |
aLD50 values determined in the test were compared to values available in Material Safety Data sheets provided with the compounds. Blank space indicates the data are not available
bCompounds tested at >100 mg/Kg were initially tested in 50% DMSO (which is toxic to G. mellonella) and then re-tested at lower [DMSO]s such that the final [DMSO] was 10%