Table 2.
Patient characteristics and perioperative clinical data in the low and high inflammatory response groups
| LIR group n = 20 | HIR group n = 22 | |
|---|---|---|
| Preoperative parameters | ||
| Age (year)a | 68 ± 6 | 69 ± 7 |
| Gender (n) F / Mb | 9 / 11 | 11 / 11 |
| Body mass index (kg/m2)c | 29.4 (24.7–33.0) | 27.2 (25.4–28.8) |
| Education (year)c | 11 (11–12) | 12 (11–12) |
| BDI (score)c | 9 (5.3–14.3) | 8.0 (5.0–10.0) |
| STAI-state (score)a | 41.9 ± 10.3 | 41.2 ± 11.4 |
| EuroSCORE (%)c | 3.9 (2.8–5.7) | 4.3 (2.7–7.6) |
| HTN (n)b | 15 | 14 |
| DM (n)b | 5 | 6 |
| CAD (n)b | 8 | 9 |
| PVD (n)b | 3 | 2 |
| COPD (n)b | 3 | 4 |
| Left ventricle EF (%)c | 55 (55–67) | 55 (50–60) |
| Creatinine (μmol/L)a | 74.3 ± 12.6 | 84.0 ± 21.9 |
| Antihypertensives (n)b | 15 | 14 |
| Statin use (n)b | 11 | 5 |
| Antiplatelet drug (n)b | 11 | 6 |
| Type of surgery | ||
| CABG (n)b | 6 | 5 |
| Single valve (n)b | 11 | 13 |
| Combined (n)b | 3 | 4 |
| Intraoperative parameters | ||
| Aorta cross-clamp time (minute)a | 67 ± 22 | 64 ± 20 |
| CPB time (minute)a | 92 ± 23 | 91 ± 22 |
| Rewarming time (minute)c | 18 (14–22) | 17 (10–21) |
| CPB temperature (°C)c | 35.0 (34.7–35.4) | 35.2 (34.7–35.5) |
| Operation time (minute)a | 193 ± 27 | 181 ± 41 |
| Bispectral indexa | 44.3 ± 6.0 | 43.1 ± 5.6 |
| Propofol (mg/kg/h)a | 4.1 ± 1.5 | 4.3 ± 1.3 |
| Sufentanyl (μg/kg/h)c | 0.27 (0.2–0.35) | 0.28 (0.21–0.3) |
The results are presented as the mean ± standard deviation, median (interquartile range) and number of patients
aunpaired t test
bχ2 test and Fischer’s exact test
cMann-Whitney U test. LIR low inflammatory response, HIR high inflammatory response, F female, M male, BDI Beck Depression Inventory, STAI State-Trait Anxiety Inventory, HTN hypertension, DM diabetes mellitus, CAD coronary artery disease, PVD peripheral vascular disease, COPD chronic obstructive pulmonary disease, EF ejection fraction, CABG coronary artery bypass graft, and CPB cardiopulmonary bypass. There are no significant differences between the two groups regarding all parameters listed in this table