Table 6.

True positive, true negative, sensitivity and specificity for CIN2+ in different studies using ASC-US+ as cut-off

Study	TP	TN	FP	FN	SE (%)	SP (%)	AU (%)	PPV (%)	NPV (%)
Katki 2011 [10]	1 226	318 093	11 415	1 084	53.12	96.51	78.41	9.72	99.71
Dillner 2008 [15]	242	22 883	1 031	139	63.51	95.72	79.61	19.01	99.42
Castle 2012 [16]	136	18 190	926	260	34.32	95.22	64.72	12.81	98.61
Szarewski 2008 [17]	256	236	444	17	93.81	34.72	64.22	36.61	93.32
Sørbye 2011 [18]	48	92	77	8	85.71	54.42	70.12	38.41	92.02
Total	1 908	359 494	13 893	1 508	55.9	96.3	76.1	12.1	99.6

TP true positive, TN true negative, FP false positive, FN false negative, SE sensitivity, SP specificity, AU = AUROC = accuracy = (SE+SP)/2, PPV positive predictive value, NPV negative predictive value, ASC-US+ = ASC-US, LSIL, ASC-H and HSIL, CIN2+ = CIN2, CIN3 and cancer

¹Significantly higher than the average (p<0.05)

²Significantly lower than the average (p<0.05)