Figure 1. Functional and genomic assessment of schizophrenia-derived glial progenitor cells.
This schematic summarizes the steps involved in our analysis of glial progenitor cells derived from individuals with juvenile-onset schizophrenia, compared to GPCs derived from behaviorally-normal controls. The major output data include effects of SCZ origin on in vivo oligodendrocyte maturation and myelination (Figure 2); in vivo astrocyte differentiation and phenotype (Figure 3); in vitro differential gene expression (Figures 4 and 5); and behavioral phenotype of the human glial chimeric host animals (Figure 6).