Table 1.
Relationship between LINE-1 methylation level and clinicopathological parameters
| No. | Average | SD | P-value | |
|---|---|---|---|---|
| Sex | ||||
| M | 121 | 75.48 | 7.173 | 0.233 |
| F | 51 | 76.97 | 8.216 | |
| Age | ||||
| <64 years | 87 | 75.97 | 8.274 | 0.936 |
| ≥64 years | 85 | 75.87 | 6.674 | |
| Gross type | ||||
| Mass forming | 141 | 75.66 | 7.616 | 0.702 (ANOVA) |
| Periductal infiltrative | 8 | 78.62 | 3.790 | 0.558 (KW) |
| Intraductal growth | 18 | 76.73 | 7.110 | |
| Mixed | 5 | 76.16 | 10.837 | |
| Multiplicity | ||||
| single | 147 | 75.73 | 7.898 | 0.422 |
| multiple | 25 | 77.04 | 4.501 | |
| T stage | ||||
| pT1 | 48 | 78.08 | 6.972 | 0.049 (ANOVA) |
| pT2a | 38 | 73.08 | 9.417 | 0.012 (KW) |
| pT2b | 14 | 76.12 | 4.010 | |
| pT3 | 47 | 76.04 | 7.026 | |
| pT4 | 25 | 75.74 | 6.622 | |
| N stage | ||||
| pN0 | 133 | 75.96 | 7.861 | 0.899 |
| pN1 | 39 | 75.78 | 6.223 | |
| M stage | ||||
| pM0 | 161 | 76.17 | 7.593 | 0.095 |
| pM1 | 11 | 72.26 | 4.972 | 0.035 (MWa) |
| TNM stage | ||||
| I | 40 | 77.81 | 7.579 | 0.229 |
| II | 37 | 74.42 | 8.747 | |
| III | 30 | 76.25 | 7.801 | |
| IV | 65 | 75.45 | 6.406 | |
| Differentiation | ||||
| Well | 23 | 79.69 | 4.766 | 0.014 |
| Moderate | 94 | 75.95 | 6.857 | |
| Poorly | 55 | 74.28 | 8.906 | |
| Neural invasion | ||||
| Absent | 118 | 75.77 | 8.146 | 0.701 |
| Present | 54 | 76.25 | 5.921 | |
| Lymphatic invasion | ||||
| Absent | 102 | 76.92 | 7.200 | 0.034 |
| Present | 70 | 74.46 | 7.749 | |
| Vascular invasion | ||||
| Absent | 95 | 76.44 | 8.141 | 0.396 |
| Present | 77 | 75.27 | 6.631 | 0.047 (MWa) |
| Chronic liver disease | ||||
| Absent | 130 | 75.95 | 7.497 | 0.936 |
| Present | 42 | 75.84 | 7.617 | |
| Chronic biliary disease | ||||
| Absent | 159 | 75.93 | 7.679 | 0.962 |
| Present | 13 | 75.82 | 5.108 | |
aMann-Whitney