Table V. Multivariate analysis of the association of E-cadherin and N-cadherin expression on overall survival.

Variable		Hazard ratio (95% CI)	p-Value*
Membranous E-cadherin	Primary melanoma	5.06 (0.83-30.90)	0.080
	Metastatic melanoma	3.01 (0.60-15.20)	0.180
Membranous N-cadherin	Primary melanoma	0.31 (0.10-0.98)	0.046
	Metastatic melanoma	1.79 (0.57-5.64)	0.320
Aberrant E-cadherin expression	Primary melanoma	3.79 (1.13-12.72)	0.030
	Metastatic melanoma	4.07 (1.01-16.38)	0.048
Switch from E-cadherin to N-cadherin	Metastatic melanoma	0.23 (0.03-1.52)	0.130
Tumor depth	Increasing	1.09 (1.00-1.19)	0.049
Gender	Male vs. female	7.59 (1.90-30.40)	0.004
Age at diagnosis	Increasing	0.99 (0.96-1.02)	0.560

CI: Confidence interval.

^*By Cox model.