TABLE IV.

Factors associated with survival in multivariate analysis

Factor	Survival type
	Progression-free			Overall
	HR	95% CI	p Value	HR	95% CI	p Value
Performance status > 0	1.25	0.47 to 3.3	0.66	1.5	0.5 to 4.5	0.46
Liver metastases	0.52	0.16 to 1.67	0.27	1.12	0.27 to 4.55	0.88
Time from diagnosis of mCRC ≤ 18 months	0.90	0.36 to 2.2	0.81	—	—	—
Initial dose ≤120 mg	—	—	—	0.46	0.17 to 1.2	0.11

HR = hazard ratio; CI = confidence interval; mCRC = metastatic colorectal cancer.