Figure 5. Tra1 is structurally homologous to DNA-PKcs.

DNA-PKcs (PDB code 5LUQ) was superposed with Tra1, and regions of DNA-PK analogous to Finger, Ring, Clasp, FAT, FRB and Kinase are coloured according to the scheme given in Figure 1C and D. Front and side views are shown and highlight their similar topology.

Figure 5—figure supplement 1. HEAT domain comparison with mTOR, ATM and DNA-PKcs.

Tra1 was structurally aligned with mTOR (PDB code 5FLC), ATM (PDB code 5NP1) and DNA-PKcs (PDB code 5LUQ) via their conserved kinase domains. The HEAT, FAT, FRB, Kinase and FATC domains are coloured grey, green, orange, yellow and red respectively. The conformations of the FAT, FRB, Kinase and FATC domains are similar, but the the HEAT domain follows a completely different trajectory in both proteins.