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(A) PLPs circulate freely within blood due to no interactions with fibrinogen. (B) PLPs selectively bind fibrin protofibrils that begin to appear in the early stages of clot formation. (C) As the fibrin network grows, PLPs bond to multiple fibrin fibres. (D) The bonding interaction between PLPs and the fibrin network causes destabilisation and subsequent collapse of the network, in turn densifying the clot.
