Table 5.

Significant PRCC values for parameters driving fibroblast number within and on the periphery of the granuloma with no fibroblast movement and fixed TGF-β1 fibroblast proliferation threshold at day 300 PI. p < 0.01

Parameter	Description	PRCC	p value
Fibroblasts within the granuloma
γ7	Threshold for TNFα induced apoptosis	0.09	7.07*10−4
μ1	Fraction of grid compartments with a macrophage	0.07	9.85*10−3
μ11	TGF-β1 synthesis by macrophage	−0.55	1.57*10−116
μ17	Fraction of inactive TGF-β1 activated by a mac	−0.12	6.82*10−6
μ18	Amount of TGF-β1 that inhibits macrophages	−0.07	7.44*10−3
ζ7	Bound molecules of IL10 that inhibits fibroblast proliferation	0.42	5.33*10−11
ζ8	TGF-β1 myofibroblast differentiation threshold	0.17	5.74*10−6
ζ11	TNFα fibroblast proliferation threshold	0.12	8.50*10−12
ζ15	Fibroblast sensitivity to TGF-β1	0.11	7.90*10−3
ω3	Degradation rate of αSMA	0.07	3.73*10−5
Fibroblasts on the periphery of the granuloma
γ7	Threshold for TNFα induced apoptosis	0.10	6.93*10−5
μ11	TGF-β1 synthesis by macrophage	−0.38	6.15*10−52
μ17	Fraction of inactive TGF-β1 activated by a mac	−0.13	1.04*10−6
μ19	Fraction of active TGF-β1 in a compartment bound by a mac	0.28	4.57*10−27
ζ7	Bound molecules of IL10 that inhibits fibroblast proliferation	0.19	1.33*10−13
ζ11	TNFα fibroblast proliferation threshold	−0.28	1.70*10−27
ζ16	Probability of a fibroblast differentiating into a myofibroblast	−0.08	3.47*10−3
ζ15	Fibroblast sensitivity to TGF-β1	0.07	7.24*10−3