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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Brain Res. 2017 Jul 11;1672:10–17. doi: 10.1016/j.brainres.2017.07.003

Figure 2.

Figure 2

The uptake rate constant (k-1) in the FC is significantly decreased 24 h after DOX treatment. (A) The depth profile of the k-1 in the FC reveals depth-dependent sensitivity to DOX treatment; especially at the depth of -2.5 mm, which corresponds to the infralimbic cortex (*p<0.05). (B) When the depths were averaged, a 45% decrease of the k-1 in DOX-treated mice is demonstrated in comparison to saline treated animals (Saline=6, DOX=9; *p<0.05). (C) In the DG, there were no significant changes in k-1 due to DOX treatment in comparison to saline treatment (n=4/group). Statistical analyses were carried out using a RM 2-way ANOVA and a unpaired 2-tailed Student's t-test. Error bars represent the mean ± SEM.