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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Brain Res. 2017 Jul 11;1672:10–17. doi: 10.1016/j.brainres.2017.07.003

Figure 3.

Figure 3

Clearance times are significantly slower in the DG after DOX treatment. (A) The depth profile of the T80 shows that clearance times as a function of depth and (B) combined to represent the entire region did not differ as a function of treatment (n=6-9). (C) Representative traces (baseline subtracted out) demonstrate the changes in glutamate clearance. The black arrow is where exogenous glutamate was locally applied within the FC. (D) In the DG, a 48% increase in clearance time as a function of DOX treatment (n=7) was also measured in comparison to saline treatment (n=6; *p<0.05). Statistical analyses were carried out using a 2-way ANOVA and unpaired 2-tailed Student's t-tests. Error bars represent the mean ± SEM.