Workflow schematic describing the initial gene expression meta-analyses, and the subsequent studies of significant gene sets. ALI, acute lung injury; BAL, bronchoalveolar lavage; ES, effect size; FDR, false discovery rate; GEO, Gene Expression Omnibus; KEGG, Kyoto Encyclopedia of Genes and Genomes; LINCS, Library of Network-Based Cellular Signatures; NIH, U.S. National Institutes of Health.