Table 4.

Top 20 Drugs that Are Anticorrelated with Lung Injury Gene Signature in Both Human and Animal Models

Drug	Effect Human	q Value Human	Animal Effect size	Animal q Value
PD98059	−0.418	1.1E−09	−0.467	2.7E−48
AZ628	−0.395	1.5E−08	−0.463	2.3E−47
Fostamatinib	−0.392	2.1E−08	−0.491	4.1E−54
AS605240	−0.374	1.2E−07	−0.434	4.5E−41
ERK inhibitor 11E	−0.367	2.4E−07	−0.478	5.2E−51
AS703026	−0.357	5.8E−07	−0.345	5.2E−25
PD0325901	−0.355	6.5E−07	−0.321	1.7E−21
PD184352	−0.353	7.6E−07	−0.362	9.7E−28
Atorvastatin	−0.352	8.7E−07	−0.468	1.2E−48
Orteronel	−0.349	1.1E−06	−0.212	2.2E−09
BRDK70153099	−0.340	2.4E−06	−0.088	2.5E−02
BRDK27064849	−0.339	2.6E−06	−0.109	4.4E−03
BRDK29622226	−0.321	1.1E−05	−0.331	7.2E−23
Selumetinib	−0.320	1.2E−05	−0.383	3.2E−31
BRDK04986062	−0.313	2.0E−05	−0.182	4.7E−07
Lapatinib	−0.305	3.7E−05	−0.387	6.6E−32
BRDK87010407	−0.299	6.0E−05	−0.101	9.0E−03
Vemurafenib	−0.299	6.1E−05	−0.231	4.8E−11
OM137	−0.296	7.2E−05	−0.233	3.2E−11
Trametinib	−0.295	7.7E−05	−0.305	2.4E−19

Definition of abbreviation: ERK, extracellular signal regulated kinase.