Table 2.

Efficacy of Various Exogenous and Endogenous Cannabinoids to Alleviate Nausea-Induced Conditioned Gaping and Contextually Elicited Conditioned Gaping in Rats

Compound	Dose details	Efficacy in acute nausea-induced gaping	Efficacy in contextually elicited gaping
CB1 receptor agonists
THC	0.5 mg/kg, i.p.  30 min pretreatment	Compared to VEH: • More effective (Limebeer and Parker59; Parker and Mechoulam60; Parker et al.61)	Compared to VEH: • More effective (Limebeer et al.78; Rock et al.79)Compared to 5-HT3 receptor antagonist: • More effective (Rock et al.79)
Endocannabinoid manipulations
Anandamide		Not evaluated	Not evaluated
2-AG	1.5, 2 mg/kg, i.p. 15 min pretreatment 0.5, 1 μg, bilaterally, after acute nausea test	Compared to VEH: • More effective (Sticht et al.67) Administration to the IC, compared to VEH: • More effective (Sticht et al.57)	Not evaluated
FAAH inhibition
PF-3845	10 mg/kg, i.p. 120 min pretreatment 2 ug, bilaterally, 30 or 70 min pretreatment	Compared to VEH: • More effective (Rock et al.64) Administration to the IC, compared to VEH: • As effective (Sticht et al.76)	Compared to VEH: • More effective (Rock et al.64) Administration to the IC, compared to VEH, 5-HT3 receptor antagonist: • As effective (Limebeer et al.83)
MAGL inhibition
MJN110	10, 20 mg/kg, i.p. 120 min pretreatment 2 ug, bilaterally, 30 or 70 min pretreatment	Compared to VEH: • More effective (Parker et al.68) Administration to the IC, compared to VEH: • More effective (Sticht et al.76)	Compared to VEH: • More effective (Parker et al.68) Administration to the IC, compared to VEH: 5-HT3 receptor antagonist: • More effective (Limebeer et al.83)
Dual FAAH/MAGL inhibition
JZL195	10 mg/kg, i.p. 120 min pretreatment	Not evaluated	Compared to VEH: • More effective (Limebeer et al.82)

CB₁, cannabinoid 1; 2-AG, 2-arachidonylglyercol; FAAH, fatty acid amide hydrolase; IC, insular cortex; MAGL, monoacylglycerol lipase.