Table 3.

CMS evidence of organ dysfunction.

Lactate > 2 mmol/L

INR > 1.5 or aPTT > 60 seconds

Platelet count < 100,000 μL−1

Bilirubin > 2mg/dL

Creatinine > 2 mg/dL

Urine output < 0.5mL/kg/hour × 2 hours

Acute respiratory failure by need for new invasive or noninvasive ventilation.

Systolic blood pressure < 90 mm Hg or MAP < 65 mm Hg or decreased in SBP more than 40 mm Hg from previously recorded patient normal.

CMS, Centers for Medicare and Medicaid Services; INR, international normalized ratio; aPTT, activated partial thromboplastin time, MAP, mean arterial pressure; SBP, systolic blood pressure.