Fig 1. Comparison of the effects of the “Radiprodil and Tozadenant” combination with the effects of L-Dopa on the level of locomotor activity in MPTP-treated marmosets.

Left graph: Lomotor activity (mean value ± SEM) measured over 10 hours following Radiprodil (2 mg/kg) and Tozadenant (150 mg/kg) treatment given alone or in combination in MPTP-treated marmosets (n = 12). Five hours after the first drug administration, a second administration was given and, at the same time, novel objects were introduced in the testing cage. * versus Radiprodil group (one-way ANOVA, p<0.01, followed by planned contrasts). Right graph: Locomotor activity measured over 5 hours follwing L-Dopa (8 mg/kg). p<0.001 L-Dopa vs Vehicle (Student test on total score).