Table 2. Expression of H. pylori genes known to be related to iron metabolism.
| Iron replete | Iron restricted/replete | ||||
|---|---|---|---|---|---|
| condition: | ratio in: | ||||
| Gene designation and category | Gene name | IDA/control ratio a | p value | Control | IDA |
| Non-heme iron ferritin: | |||||
| HP0653 | pfr | 1 | 1 | 0.1 b | 0.3 b |
| Ferric uptake regulator: | |||||
| HP1027 | fur | 0.9 | 1 | 1 | 1.9 |
| Iron (Fe++) transport protein: | |||||
| HP0687 | feoB | 1.3 | 1 | 1.3 | 0.8 |
| Iron (Fe+++) transport protein: | |||||
| HP0807 | fecA1 | 0.9 | 1 | 11.2b | 4.0 b |
| HP0686 | fecA2 | 0.9 | 1 | 1.8 | 1.2 |
| HP1400 | fecA3 | 0.8 | 0.52 | 0.6 | 0.8 |
| Iron-regulated OMP: | |||||
| HP0876 | frpB1 | 0.2 | 0.004 | 8.4 b | 17.3 b |
| HP0915 | frpB2 | 0.6 | 0.61 | 1 | 1.3 |
| HP0916 | frpB3 | 0.9 | 0.61 | 1 | 0.9 |
| HP1512 | frpB4 | 1.1 | 1 | 1 | 1 |
a Values shown are mean of triplicate determinations.
b p values in the control versus IDA group are <0.001.