Tobacco-related respiratory bronchiolitis. Macrophages inside the alveolus contain brown smoker granules and black soot pigment. Image under polarized light demonstrated one bright birefringent silicate particle (at 12 o'clock position) and a faintly birefringent silica particle at 9 o'clock. On the left side is photomicrograph of H&E-stained tissue (original magnification 400×); on the right side is the same frame under polarized light.