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. 2017 Aug 8;114(34):9182–9187. doi: 10.1073/pnas.1700866114

Fig. 3.

Fig. 3.

Arc and protein translation are required for LTD in layer IV of visual cortex. (A) LFS (900 stimuli at 1 Hz) induces robust LTD in juvenile (P20–25) WT, but not Arc-KO, slices (average of last 5 min of recordings normalized to the baseline; WT: n = 4 mice, KO: n = 5; *P < 0.001). (B) LFS induces LTD to the same degree in young (P26–41) WT and Arc-Tg slices (WT: n = 7, Arc-Tg: n = 6; P > 0.5). The LTD amplitudes of field excitatory postsynaptic potential (fEPSP) of the youngest animals in this group (P26–33, circles) and the older animals (P34–41, inverted triangles) do not show any significant difference (P > 0.5, t test), and were therefore combined. (C) LFS induces robust LTD in adult (P180–200) Arc-Tg slices, but not WT slices (WT: n = 11, Arc-Tg: n = 6; *P = 0.04). (D) LFS induced LTD in juvenile (P25–30) visual cortex previously infused with saline, but not in visual cortex infused with CHX (saline: n = 5, CHX: n = 5; *P = 0.02). Data are represented as mean ± SEM.