Fig. S1.
Nisoldipine inhibits basal and β-adrenergic–stimulated endogenous CaV1.2 current equivalently. (A) Diary plot of Ca2+ current (ICa) amplitude at +10 mV in picoamperes per picofarad (pA/pF) before, after 200 nM isoproterenol, and after 300 nM nisoldipine in presence of 200 nM isoproterenol from nontransgenic mouse. Data are representative of seven similar experiments. (B) Bar graph of fraction current remaining after nisoldipine in cells without isoproterenol (ISO) superfusion (n = 12) and cells with isoproterenol superfusion (n = 7). Mean ± SEM (P = 0.75 by unpaired t test).