Fig. 2.
Overview of the Ugt1a genomic locus on mouse chromosome 1, and the sequence variation in the exon shared by multiple Ugt1a genes. The genes that were found mutated in the C57BL/6NJ strain, Ugt1a1, Ugt1a6a, Ugt1a7c, Ugt1a5, Ugt1a9, Ugt1a2, and Ugt1a10, all make use of a common exon. In this exon, the affected codon leading to the mutation (R > S) is found, and is enlarged in the figure and labeled in red. For each gene, this relevant sequence change leads to a specific mutation; for example, for Ugt1a10 and Ugt1a10R439S.