Table 2.
Examples of known mutations, validated by mousepost.be, and new interstrain gene variations, as described in this report
| Known mutation/gene | Variation found by mousepost.be | PROVEAN score | Mouse strain | (Expected) phenotype and reference |
| Lpsd/Tlr4 | Tlr4P712H | −7.833 | C3H/HeJ | Resistance to LPS (7) |
| Albino/Tyr | TyrC103S | −9.738 | BALB/cJ | Albinism (13) |
| CyfipM1N/Cyfip2 | Cyfip2S968F | −5.251 | C57BL/6NJ | Retinal degeneration (17) |
| Interstrain gene variants/gene | ||||
| Rd8/Crb1 | Crb1R1161G | NA: SG: 14% shorter protein | C57BL/6NJ | Response to cocaine and methamphetamine (18) |
| Adamts12 | Adamts12C1518F | −7.131 | C57BL/6NJ | Cancer phenotype (19) |
| Ugt genes | R > S | −4.545 to −4.791 | C57BL/6NJ | Poor detoxification |
| Adamts4 | Adamts4L17F | NA: SG: 96% shorter protein | FVB/NJ | Resistance to atherosclerosis (22) |
| Ccr5 | Ccr5P185L | −9.103 | FVB/NJ | Resistance to acetaminophen (23–25) |
| Brca1 | Brca1N623S | −3.369 | CAST/EiJ | Breast cancer susceptibility |
| Brca2 | Brca2L1495del | −12.166 | CAST/EiJ | Breast cancer susceptibility |
| Nlrp3 | Nlrp3P214A | −7.090 | CAST/EiJ | Deficient NLRP3 inflammasome function |
| Tnfrsf1b | Tnfrsf1bP431L | −7.325 | 129 strains | Resistance to TNF-mediated inflammation |
| BTBR T+ Itpr3tf/J | ||||
| LP/J | ||||
| Ripk3 | Ripk3T166K | −5.114 | BTBR T+ Itpr3tf/J | Resistance to necroptosis |
| DBA/2J | ||||
| IL1a | IL1aY118_T119del | −11.218 | C3H/HeN | Resistance to IL1α-mediated inflammation |
| C3H/HeJ | ||||
| Il1r1 | Il1r1E500G | −6.401 | PWK/PhJ | Resistance to IL1-mediated inflammation |