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A framework for prioritizing coronary artery disease (CAD) genes using network-based approaches. The workflow contains 4 steps, including (A) retrieving CAD gene lists from genome-wide association studies (GWAS) and other functional studies, (B) key driver (KD) analysis, (C) scoring and ranking based on network consistency of KD analysis, GWAS gene annotation, and gene expression profiles between myocardial infarction and normal subjects, and (D) in silico validation.
