Table 1.
Top Multitissue KD Genes in Gene Regulatory and Protein–Protein Interaction Networks Ranked by KD Analysis Meta P Value Across CAD Gene Lists and Networks
| KD | Ad | Ao | Ar | Bl | Br | CM | Ht | Is | Kd | Li | Mu | PP | SM | VE | Tissue Consist | List Consist | Meta P Values | KD P Values in 1000G CAD GWAS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DUSP6 | 0 | 2 | 2 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 2 | 5 | 15 | 1.35e−34 | 1.47e−03 |
| DUSP1 | 0 | 1 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 3 | 11 | 2.77e−26 | 2.07e−03 |
| KNG1 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 2 | 9 | 8.60e−15 | 2.65e−03 |
| F2 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 2 | 9 | 4.22e−13 | 2.62e−04 |
| APOA1 | 4 | 0 | 0 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 3 | 11 | 1.93e−09 | 5.60e−05 |
| HGD | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | 0 | 2 | 9 | 1.05e−08 | 4.15e−03 |
| GBP1 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3 | 6 | 3.41e−08 | 6.76e−04 |
| GBP2 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 2 | 0 | 3 | 6 | 1.60e−07 | 6.76e−04 |
| ANXA1 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2 | 4 | 9.70e−07 | 9.12e−03 |
| PLG | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 5 | 3.13e−06 | 2.88e−34 |
| COL4A2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 3 | 0 | 0 | 2 | 7 | 4.04e−06 | 1.83e−10 |
| MSN | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 2 | 3 | 7.30e−06 | 1.00e+00 |
| ANXA2 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 4 | 1.47e−05 | 3.43e−03 |
| CXCL12 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 3 | 1 | 0 | 0 | 0 | 4 | 6 | 2.28e−05 | 2.95e−10 |
| ABCG5 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 3 | 3.70e−05 | 1.35e−07 |
| APOB | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 2 | 5 | 6.48e−05 | 3.09e−08 |
| ADM | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2 | 2 | 7.95e−05 | 2.77e−04 |
| RDH16 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 2 | 4 | 0.000115 | 3.17e−03 |
| PAPSS2 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | 3 | 0.000136 | 4.68e−03 |
| APOA5 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 3 | 0.0005 | 5.60e−05 |
| FN1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 3 | 0 | 0 | 2 | 4 | 0.000759 | 5.14e−07 |
| IRF7 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 2 | 0.000912 | 8.68e−03 |
The numbers in each cell represent how many of the 7 CAD gene lists yielded the KD using the specific tissue network. Ad indicates adipose; Ao, aorta; Ar, artery; Bl, blood; Br, brain; CAD, coronary artery disease; CM, cardiac muscle; GWAS, genome-wide association studies; Ht, heart; Is, islet; Kd, kidney; KD, key driver; Li, liver; Mu, muscle; PP, protein–protein interaction; SM, smooth muscle; and VE, vascular endothelium networks.