Table 3.

Top 20 KDs Based on an Overall Ranking Score Derived From 3 Data-Driven Criteria

KD	Meta P Value for KDA	P Value for GWAS Enrichment	Meta P Value for Differential Expression	Score 1 (KDA Strength and Consistency)	Score 2 (Subnetwork Enrichment for CARDIoGRAM-C4D GWAS Signals)	Score 3 (Gene Expression Alterations Between CAD and Controls)	Summary Score
LUM	5.74e−08	1.14e−03	1.38e−13	0.935	0.923	0.978	2.836
COL1A1	4.13e−06	1.14e−03	1.55e−05	0.848	0.923	0.819	2.590
DUSP6	1.35e−34	6.82e−03	1.00e−16	1.000	0.538	1.000	2.538
HGD	1.05e−08	1.14e−03	3.76e−02	0.957	0.923	0.616	2.496
MSN	7.30e−06	4.55e−03	4.44e−16	0.826	0.619	0.993	2.438
CXCL12	2.28e−05	1.14e−03	1.62e−02	0.797	0.923	0.652	2.372
DUSP1	2.77e−26	1.02e−02	2.46e−08	0.993	0.427	0.928	2.348
GBP2	1.60e−07	3.41e−03	9.42e−04	0.920	0.698	0.725	2.343
MTMR11	8.93e−07	1.14e−03	3.61e−01	0.913	0.923	0.486	2.322
CCL18	1.39e−06	9.09e−03	8.61e−11	0.877	0.474	0.949	2.300
SLIT3	2.04e−04	1.00e−03	2.44e−01	0.717	1.000	0.507	2.225
GBP1	3.41e−08	1.82e−02	1.05e−11	0.942	0.226	0.964	2.132
F2	4.22e−13	1.14e−03	9.53e−01	0.971	0.923	0.232	2.126
COL4A2	4.04e−06	5.68e−03	1.94e−03	0.855	0.582	0.688	2.126
LOXL2	1.68e−04	3.41e−03	2.96e−02	0.725	0.698	0.638	2.061
CXCL10	2.74e−04	1.02e−02	3.37e−12	0.659	0.427	0.971	2.058
ANXA3	3.06e−03	1.14e−03	7.02e−07	0.246	0.923	0.877	2.046
SLC2A3	2.74e−04	7.95e−03	4.76e−07	0.652	0.500	0.884	2.036
SHC1	4.26e−03	1.14e−03	1.32e−09	0.167	0.923	0.942	2.032
STAT3	3.50e−03	1.00e−03	3.27e−05	0.210	1.000	0.812	2.022

CAD indicates coronary artery disease; CARDIoGRAM-C4D, Coronary Artery Disease Genome Wide Replication and Meta-Analysis Plus the Coronary Artery Disease Consortium; KDA, key driver analysis; and GWAS, genome-wide association studies.