Table 4.
KD | PolySearch (Z Score >0.5) | COREMINE (Significance <10e−4) | Top Associated Diseases in Linguamatics (PubMed >5)* | Drug Development† | Druggability‡ |
---|---|---|---|---|---|
LUM | No | No | Melanoma, myopia, breast neoplasms | N/A | Yes |
COL1A1 | No | Yes | Osteogenesis imperfecta, otosclerosis, osteoporosis | Cancer, solid, unspecified; macular degeneration, age; scleroderma | Yes |
DUSP6 | No | No | Malignant neoplasm pancreas, carcinogenesis, obesity | N/A | N/A |
HGD | No | No | Alkaptonuria, metabolic diseases, Barrett esophagus | N/A | N/A |
MSN | No | No | Neoplasm metastasis, pseudohermaphroditism female | N/A | N/A |
CXCL12 | Yes | Yes | Diabetes mellitus, ischemia, myocardial infarction | Infection, HIV/AIDS; cancer, unspecified; infarction, myocardial | Yes |
DUSP1 | No | No | Malignant neoplasm, diabetes mellitus | N/A | N/A |
GBP2 | No | No | Breast neoplasms, neoplasm metastasis, vesicular stomatitis | N/A | N/A |
MTMR11 | No | No | Obesity, prostatic neoplasms, atherosclerosis | N/A | N/A |
CCL18 | No | No | Breast carcinoma | N/A | N/A |
SLIT3 | No | No | Breast neoplasms, rheumatoid, brain ischemia | N/A | N/A |
GBP1 | No | No | Inflammatory bowel diseases, vascular diseases | Anticancer, other; Gene therapy | Yes |
F2 | Yes | Yes | Thrombosis, myocardial infarction, stroke | Thrombosis; cardiovascular disease, unspecified; atherosclerosis | Yes |
COL4A2 | No | Yes | Anoxia, cerebral hemorrhage, edema | N/A | N/A |
LOXL2 | No | No | Tumor progression | Anticancer, other; hepatoprotective; respiratory; vulnerary | Yes |
CXCL10 | No | Yes | Communicable diseases, infection, inflammation | Traumatic brain injury; Crohn’s disease; arthritis, rheumatoid | Yes |
ANXA3 | No | No | Neoplasm metastasis, ovarian neoplasms, prostatic neoplasms | N/A | Yes |
SLC2A3 | No | No | Carcinoma, squamous cell; lipidoses | N/A | Yes |
SHC1 | Yes | No | Breast neoplasms, carcinogenesis, diabetes mellitus | Neurological disease, unspecified; cardiovascular disease, unspecified | N/A |
STAT3 | No | No | Breast neoplasms, carcinogenesis, inflammation | Inflammatory disease, unspecified; cancer, unspecified; Alzheimer disease | Yes |
N/A indicates not applicable.
The key driver genes were searched against all the disease PubMed databases using Linguamatics.
The drug target information was collected from DrugBank and Pharmaprojects databases. The listed diseases were the most targeted ones in the drug development.