Table 4.
In Silico Validation of the Top 20 Key Driver Genes Using Text-Mining and Drug Information
| KD | PolySearch (Z Score >0.5) | COREMINE (Significance <10e−4) | Top Associated Diseases in Linguamatics (PubMed >5)* | Drug Development† | Druggability‡ |
|---|---|---|---|---|---|
| LUM | No | No | Melanoma, myopia, breast neoplasms | N/A | Yes |
| COL1A1 | No | Yes | Osteogenesis imperfecta, otosclerosis, osteoporosis | Cancer, solid, unspecified; macular degeneration, age; scleroderma | Yes |
| DUSP6 | No | No | Malignant neoplasm pancreas, carcinogenesis, obesity | N/A | N/A |
| HGD | No | No | Alkaptonuria, metabolic diseases, Barrett esophagus | N/A | N/A |
| MSN | No | No | Neoplasm metastasis, pseudohermaphroditism female | N/A | N/A |
| CXCL12 | Yes | Yes | Diabetes mellitus, ischemia, myocardial infarction | Infection, HIV/AIDS; cancer, unspecified; infarction, myocardial | Yes |
| DUSP1 | No | No | Malignant neoplasm, diabetes mellitus | N/A | N/A |
| GBP2 | No | No | Breast neoplasms, neoplasm metastasis, vesicular stomatitis | N/A | N/A |
| MTMR11 | No | No | Obesity, prostatic neoplasms, atherosclerosis | N/A | N/A |
| CCL18 | No | No | Breast carcinoma | N/A | N/A |
| SLIT3 | No | No | Breast neoplasms, rheumatoid, brain ischemia | N/A | N/A |
| GBP1 | No | No | Inflammatory bowel diseases, vascular diseases | Anticancer, other; Gene therapy | Yes |
| F2 | Yes | Yes | Thrombosis, myocardial infarction, stroke | Thrombosis; cardiovascular disease, unspecified; atherosclerosis | Yes |
| COL4A2 | No | Yes | Anoxia, cerebral hemorrhage, edema | N/A | N/A |
| LOXL2 | No | No | Tumor progression | Anticancer, other; hepatoprotective; respiratory; vulnerary | Yes |
| CXCL10 | No | Yes | Communicable diseases, infection, inflammation | Traumatic brain injury; Crohn’s disease; arthritis, rheumatoid | Yes |
| ANXA3 | No | No | Neoplasm metastasis, ovarian neoplasms, prostatic neoplasms | N/A | Yes |
| SLC2A3 | No | No | Carcinoma, squamous cell; lipidoses | N/A | Yes |
| SHC1 | Yes | No | Breast neoplasms, carcinogenesis, diabetes mellitus | Neurological disease, unspecified; cardiovascular disease, unspecified | N/A |
| STAT3 | No | No | Breast neoplasms, carcinogenesis, inflammation | Inflammatory disease, unspecified; cancer, unspecified; Alzheimer disease | Yes |
N/A indicates not applicable.
*
The key driver genes were searched against all the disease PubMed databases using Linguamatics.
†
The drug target information was collected from DrugBank and Pharmaprojects databases. The listed diseases were the most targeted ones in the drug development.