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. Author manuscript; available in PMC: 2017 Aug 30.
Published in final edited form as: Neurobiol Aging. 2014 Jan 8;35(6):1293–1300. doi: 10.1016/j.neurobiolaging.2014.01.004

Table 3.

Summary of DNA repair tests conducted in this study

Sample Repair step Substrate DNA repair activity§
Brain nuclear lysates DNA Glycosylase 5-hydroxyuracil in a bubble DNA Yes*
Ligase Nick-1 No (P=0.06)
Linearized plasmid Yes*
Brain mitochondrial lysates DNA Glycosylase 5-hydroxyuracil Yes*
Uracil No
AP endonuclease Abasic site No
Polymerase Gap No (p=0.056)
Ligase Nick-1 Yes*
Nick-2 Yes*

In the column#4 titled DNA repair activity, the symbol § indicates whether there is a significant decrease in repair activity in the AD samples relative to control samples. In each row within this column, * symbol indicates that the p-value is <0.05. in cases of no difference but with a trend we indicated the p-values. Nick-1 is a heteroduplex with a 5′-P and 3′OH containing nick, where as Nick-2 is a heteroduplex with a nick containing 3′- and a 5′-OH groups. Nick to is generated by gap filling activity by a polymerase on a gap substrate.