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. 2017 Apr 19;28(9):2618–2630. doi: 10.1681/ASN.2016070789

Figure 1.

Figure 1.

Thrombin inhibition reduces proteinuria in the PAN-induced and hDTR rat models of NS. (A) Rats were given 50 mg/kg PAN (intravenous) on day 0, both twice daily subcutaneous hirudin (1 mg/kg; n=8) and daily intravenous AT (500 IU/kg; n=7) reduced day 10 mean±SEM urine protein-to-creatinine ratio versus control animals (n=8), which received sham treatment with the carrier solution (normal saline) by both routes at the respective frequencies. (B) Rats were given 25 ng/kg DT (intraperitoneal) on day 0. Twice daily hirudin (1 mg/kg; n=5) reduced day 10 mean±SEM urine protein-to-creatinine ratio versus control animals (n=4) receiving sham treatment. *P<0.05 versus day 0; #P<0.05 versus control.