Table 4.
Annual rate of eGFR decline by quartile of biomarker concentrations in VA-NEPHRON-D
| Variable | Mean eGFR Decline in ml/min per 1.73 m2 per yr (SEM) | P Value |
|---|---|---|
| TNFR-1, pg/ml | 0.01 | |
| ≤3104 | −2.75 (0.18) | |
| 3105–4186 | −3.33 (0.17) | |
| 4187–5810 | −3.58 (0.18) | |
| ≥5811 | −3.33 (0.19) | |
| TNFR-2, pg/ml | <0.001 | |
| ≤8182 | −2.52 (0.18) | |
| 8183–10699 | −3.47 (0.17) | |
| 10,700–13,813 | −3.68 (0.18) | |
| ≥13,814 | −3.39 (0.20) | |
| KIM-1, pg/ml | <0.001 | |
| ≤235 | −2.00 (0.17) | |
| 236–406 | −3.08 (0.17) | |
| 407–709 | −3.34 (0.18) | |
| ≥710 | −5.46 (0.21) | |
Annual rate of decline derived from linear mixed models accounting for baseline eGFR, treatment arm, biomarker strata, and follow-up time.