Figure 10.
ILK knockdown attenuates renal cyst development in pcy mice. (A) Representative images of kidney cross-sections of Ilk+/+;pcy/pcy (Ilk+/+ pcy) and Ilkfl/+;Pkhd1-Cre;pcy/pcy (Ilk+/− pcy) mice at 10 weeks of age. Images were taken at the same magnification. Scale bar=1 mm. (B) Heterozygous loss of ILK in CD cells had no effect on body weight. However, there was a dramatic reduction in (C) kidney weight (% body weight), (D) cystic index, and (E) cyst number per section in Ilk+/−pcy mice compared with Ilk+/+ pcy mice. *P<0.05, ***P<0.001 compared with Ilk+/+ pcy mice.