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. 2017 May 18;28(9):2708–2719. doi: 10.1681/ASN.2016111235

Figure 4.

Figure 4.

ILK knockdown decreases cyst growth and kidney weight in PKD mice. Representative images of (A) kidneys and (B) kidney sections from Ilk+/+;Pkd1fl/fl;Pkhd1-Cre (Ilk+/+ PKD), Ilkfl/+;Pkd1fl/fl;Pkhd1-Cre (Ilk+/−PKD), Ilkfl/fl;Pkd1fl/fl;Pkhd1-Cre (Ilk−/− PKD), and WT mice demonstrate that the loss of ILK expression in CD cells reduced cyst growth in PKD mice. All images were taken at the same magnification. Scale bar=1 mm. Bar graphs are mean±SEM for (C) Body weight and (D) kidney weight as a percentage of body weight (% body weight) for n=10 mice per group. (E) Cystic index is represented as the percentage of cystic area per total kidney cross-sectional surface area for n=7 mice per group. **P<0.01 and ***P<0.001, compared with Ilk+/+ PKD mice.