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. 2017 May 18;28(9):2708–2719. doi: 10.1681/ASN.2016111235

Figure 8.

Figure 8.

ILK knockdown reduces renal interstitial fibrosis and improves kidney function in PKD mice. Representative kidney sections from (A) WT, (B) Ilk+/+;Pkd1fl/fl;Pkhd1-Cre (Ilk+/+ PKD), (C) Ilkfl/+;Pkd1fl/fl;Pkhd1-Cre (Ilk+/−PKD), and (D) Ilkfl/fl;Pkd1fl/fl;Pkhd1-Cre (Ilk−/− PKD) mice were stained with Masson trichrome to visualize pathogenic collagen deposition (stained blue). All images were taken at the same magnification. Scale bar=50 µm. (E) Tissue sections were coded to conceal the group assignment before being visually scored for percentage of interstitial fibrosis and edema per total area of the tissue section. Data are means±SEM for kidneys from seven mice per group. (F) Serum was isolated from WT (n=5), Ilk+/+ PKD (n=10), Ilk+/− PKD (n=10), and Ilk−/− PKD (n=7) and BUN was determined to assess renal function. ***P<0.001 compared with WT, #P<0.05 compared with Ilk+/+ PKD.