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. 2017 May 18;28(9):2708–2719. doi: 10.1681/ASN.2016111235

Figure 9.

Figure 9.

ILK knockdown increases the survival of PKD mice. (A) Kaplan–Meier survival curve for Ilk+/+;Pkd1fl/fl;Pkhd1-Cre (Ilk+/+ PKD, n=11), Ilkfl/+;Pkd1fl/fl;Pkhd1-Cre (Ilk+/−PKD, n=13), and Ilkfl/fl;Pkd1fl/fl;Pkhd1-Cre (Ilk−/− PKD, n=8) mice. The dotted line represents the time point at which 50% of the mice had died. ILK knockdown in CD cells extended the survival of PKD mice. (B) Heterozygous loss of ILK significantly increased mean survival age from 33±2 for the Ilk+/+ PKD mice to 42±2 days for the Ilk+/− PKD mice, *P<0.05. Complete loss of ILK (Ilk−/− PKD) appeared to extend survival; however, the difference did not reach statistical significance.