Table 2.
Results of the multivariate, platinum stratified, Cox model for OS (primary endpoint) and PFS using variable selection based on p-value significance. Factors in the final model in the development sample.
| OS | PFS | |||||
|---|---|---|---|---|---|---|
|
| ||||||
| Factor | HR | 95% CI | P* | HR | 95% CI | P* |
|
| ||||||
| WBC (×103/μL): | 0.013 | |||||
| 6.3 (1st Quartile) | Ref. | Ref. | ||||
| 10.3 (3rd Quartile) | 1.10 | 1.02–1.20 | ||||
|
| ||||||
| ECOG-PS: | <0.001 | <0.001 | ||||
| 0 | Ref. | Ref. | Ref. | Ref. | ||
| 1 | 1.76 | 1.37–2.26 | 1.54 | 1.25–1.90 | ||
| ≥2 | 2.39 | 1.69–3.38 | 1.81 | 1.35–2.42 | ||
| Unknown | 1.53 | 1.14–2.06 | 1.38 | 1.07–1.78 | ||
|
| ||||||
| BMI: | 0.003 | |||||
| 23.6 (1st Quartile) | Ref. | Ref. | ||||
| 29.1 (33d Quartile) | 0.80 | 0.69–0.93 | ||||
|
| ||||||
| Lung-Liver-Bone metastases: | <0.001 | <0.001 | ||||
| Yes vs No | 1.68 | 1.38–2.04 | 1.63 | 1.38–1.94 | ||
|
| ||||||
| Ethnicity: | 0.012 | |||||
| Not Hispanic/L, White | Ref. | Ref. | ||||
| Hispanic/L | 1.42 | 1.03–1.97 | ||||
| Not Hispanic/L, Black | 0.77 | 0.39–1.51 | ||||
| Other/mixed | 0.44 | 0.21–0.95 | ||||
| Unknown | 0.62 | 0.36–1.07 | ||||
|
| ||||||
| Prior peri-operative chemotherapy: | ||||||
| Yes vs No | 1.38 | 1.07–1.78 | 0.012 | 1.29 | 1.02–1.63 | 0.033 |
|
| ||||||
| Age | ||||||
| 59 (1st Quartile) | Ref. | Ref. | 0.030 | |||
| 73 (3rd Quartile) | 0.72 | 0.57–0.90 | ||||
Abbreviations: BMI: body-mass index; CI: confidence interval; ECOG-PS: Eastern Cooperative Oncology Group-Performance Status; HR: hazard ratio; L: latino; PFS: progression-free survival; OS: overall survival; WBC: white blood cell count.
*
P: two-sided Wald test p value.