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. 2017 Aug 30;7:9989. doi: 10.1038/s41598-017-10577-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of XWL-1-48 on growth of HCC in vivo. (A,B) Athymic nude mice bearing HepG2 tumor xenografts were orally administered every other day vehicle control (sterile normal saline), XWL-1-48 (2 and 4 mg/kg), and VP16 (23 mg/kg) for 15 days. Relative Tumor Volume and body weight were measured every other day. (C) The picture showed the tumor size of HepG2 xenograft at the end of the experiment. (D) Tumor tissues were weighed and further inhibitory rate of tumor weight were calculated. Data are mean ± SD of the tumor weight for each group of 7 experimental animals. (E,F) Protein expression in xenografts was determined after 15-day of XWL-1-48 or VP16 treatment. Tumors were harvested 2 h after the last dose. γ-H2AX, p-p53, p53; p-Akt, Akt, p-Mdm2 and total Mdm2 were analyzed by immunoblot analysis.