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. 2017 Aug 30;7:9974. doi: 10.1038/s41598-017-09707-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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pCREB and PTEN protein levels in human donor and idiopathic pulmonary arterial hypertension (IPAH) lungs. (a) pCREB and CREB protein levels were detected in lung tissues as 43-kDa bands and the protein levels decreased in IPAH lung tissues compared with those in donor lung tissues. (b) PTEN protein was detected as a 54-kDa band and exhibited scant expression in the IPAH lung tissue compared with that in the donor lung tissue. The bars represent the mean ± SEM of four samples in each group. *P < 0.05 and ***P < 0.001compared with the donor tissue. GAPDH = glyceraldehyde-3-phosphate dehydrogenase.