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. 2017 Aug 30;7:9974. doi: 10.1038/s41598-017-09707-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of PGE1 on the silencing of PTEN-induced PASMC proliferation and migration. Commercially available PASMCs were transfected with siRNA for PTEN or control non-targeting siRNA (scrambled siRNA). PTEN-silenced PASMCs were exposed to the PKA inhibitor (1, 5, or 10 μmol/L) or CREBi (0.1, 0.5, or 1 μmol/L) and incubated with or without PGE1 (100 nmol/L). PGE1 inhibited the proliferation and migration of PTEN-silenced PASMCs, which was reversed by a PKA (H89) and CREB inhibitors (CREB i) (a, c). PGE1 inhibited the proliferation and migration of scrambled-siRNA PASMCs were not dose-dependent reversed by PKA (H89) and CREB inhibitor (CREB i) (b, d).The bars represent the mean ± SEM, for n = 6 samples. *P < 0.05, **P < 0.01 and ***P < 0.001 compared with scrambled siRNA (a, c, d) or with serum free (b).