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. 2017 Aug 30;7:9974. doi: 10.1038/s41598-017-09707-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of PGE1 on pulmonary hemodynamics and pulmonary arterial hypertrophy. The right ventricle systolic pressure (RVSP) (a) and systemic arterial pressure (SAP) (b) measurements for 5 different groups are shown. Pulmonary hypertension (indicated by elevated RVSP) was established 28 days after MCT injection with or without PGE1 treatment and lipid/PGE1 (5 mg/kg/d administered i.p. from day 7 to day 28). The MCT/lipid/PGE1 groups exhibited reduced RVSP compared with the MCT-treated group but not reduced SAP. The ratio of RV to LV plus septum weight (RV/LV + S) is shown (c). The medial wall thickness of the small pulmonary arteries (25–75 μm) identified by α-SM-actin staining (brown staining) is shown (d). The degree of medial wall thickness was compared among the 5 groups. The mean±SEM (n = 4–8 in each group) is expressed for each group. (e) The pulmonary artery outflow measured by echocardiography is shown. ***P < 0.001 versus the control group, one-way ANOVA with Bonferroni’s post -hoc test.